B Cells with Regulatory Function in Human Diseases
نویسندگان
چکیده
A number of reports described human B cells that produce IL-10, [1-3] as potential BREGs and findings suggest that these human BREGs are potent generators of regulatory T cells (Treg) [4, 5]. Spontaneous IL-10 production by blood mononuclear cells is dramatically higher in untreated autoimmune disease patients than in healthy controls [6]. Yet, current knowledge regarding human B-cell production of IL-10 provides diverse results that are difficult to unify in a coherent model.
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